Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis
H. Bartvander Worp, Emily S. Sena, Geoffrey A. Donnan, David W. Howells and Malcolm R. Macleod
Animal studies of induced hypothermia in focal cerebral ischaemia have tested cooling throughout a wide range of target temperatures, durations and intervals between stroke onset and the initiation of hypothermia.Data from 3353 animals show hypothermia reduced infarct size by 44%. In animal models of focal cerebral ischaemia, hypothermia improves outcome by about one-third.
Influence of early posttraumatic hypothermia therapy on local cerebral blood flow and glucose metabolism after fluid-percussion brain injury
WEIZHAO ZHAO, OFELIA F. ALONSO., JUDITH Y. LOOR, RAUL BUSTO, AND MYRON D. GINSBERG
J Neurosurg, 1999
Rats were induced in either cranial hypothermia (30ºC) or normothermia (37ºC) for three hours after fluid-percussion head injury to assess local cerebral metabolic rate of glucose (LCMRglu) and local cerebral blood flow (LCBF). The LCMRglu/LCBF ratio was nearly doubled in the group that received cranial hypothermia relative to the rats that received normothermia.
Posttraumatic Hypothermia followed by Slow Rewarming Protects the Cerebral Microcirculation
EIICHI SUEHIRO, YUJI UEDA, ENOCH P. WEI, HERMES A. KONTOS, and JOHN T. POVLISHOCK
J of Neurotrauma, 2003
Rats were prepared for assessment of microcirculation prior to and after traumatic brain injury. It was found that posttraumatic hypothermia followed by slow rewarming maintained normal responses in terms of ACh-dependent dilation and CO2 reactivity. In contrast, rats subjected to traumatic brain injury followed by normothermia or hypothermia and rapid rewarming showed impaired vasoreactivity in terms of their ACh-dependent and CO2 responses. This study demonstrates that the neuroprotective effects extend to the cerebral microcirculation.