Author: neuraxis_editor

Posted on

Glutamate Release and Free Radical Production Following Brain Injury: Effects of Post traumatic Hypothermia

Glutamate Release and Free Radical Production Following Brain Injury: Effects of Post traumatic Hypothermia
Mordecai Y.-T. Globus, Ofelia Alonso, W. Dalton Dietrich, Raul Busto, and Myron D. Ginsberg
Journal of Neurochemistry, 1995

Rats were evaluated to see whether excessive extracellular release of glutamate and generation of hydroxyl radicals is associated with remote traumatic brain injury and whether posttraumtic hypothermia modulates these processes. Following trauma, brain temperature was kept at either 37ºc or 30ºC for three hours. Posttraumatic hypothermia resulted in the suppression of both hydroxyl radical production and glutamate release.

Posted on

Hypothermic Preconditioning Increases Survival of Purkinje Neurons in Rat Cerebellar Slices after an In Vitro Simulated Ischemia

Hypothermic Preconditioning Increases Survival of Purkinje Neurons in Rat Cerebellar Slices after an In Vitro Simulated Ischemia
Hui-Bih Yuan, Yueming Huang, Shuqiu Zheng, Zhiyi Zuo
Anesthesiology, 2004

Rat cerebellar cells were deprived of oxygen-glucose for 20 minutes to simulate an ischemic event in vitro. Mild hypothermia of 33ºC was applied to the cells at various times before oxygen-glucose deprivation for 20 minutes. It was found that providing hypothermia before ischemia was able to provide a phase of neuroprotection.