Resection of a Thoracic Vertebra for Hemangioma
Operation under Deep Hypothermia and Circulatory Arrest
SOINI RYOPPY, MIKKO POUSSA, OLLI HEISKANEN,
MAURI LEIJALA, AND KAIJA PELTOLA, HELSINKI, FINLAND
JB&JS, 1990
Therapeutic Hypothermia
Therapeutic Hypothermia
Joseph Varon, Pilar Acosta
Injury, 2011
Therapeutic hypothermia: Benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury
Therapeutic hypothermia: Benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury
E. M. Moore, A. D. Nichol, S. A. Bernard, R. Bellomo
Chest, 2008
Preconditioning and Hypothermic Cardioplegia Protect Human Heart Equally Against Ischemia
Preconditioning and Hypothermic Cardioplegia Protect Human Heart Equally Against Ischemia
Joseph C. Cleveland, Daniel R. Meldrum, Robert T. Rowland, Anirban Banerjee, and Alden H. Harken
The Society of Thoracic Surgeons, 1997
Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia
Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia
S. L. Hale R. H. Dave R. A. Kloner
Basic Res Cardio, 1997
Rabbits were randomly assigned to one of three groups: group 1, topical myocardial cooling starting 10 min after coronary occlusion; group 2, cooling starting 25 min after coronary occlusion; or group 3, control, no intervention. Early cooling (group 1) resulted in a significant reduction in infarct size compared to the control. However, cooling just before the reperfusion (group 2) failed to reduce infarct size compared to the control. Reducing myocardial temperature reduces infarct size but it is important that the reduction in temperature be produced as early as possible.
Effects of induced hypothermia after soft-tissue injury
Effects of induced hypothermia after soft-tissue injury
Andreas Wladis, Robert G. Hahn, Bo Brismar, B. Thomas Kjellström
Arch Orthop Trauma Surg, 2004
Normothermia or hypothermia was assigned to 14 anesthetized piglets after a gunshot wound to the right hind leg. The cardiovascular and hematological status was monitored for 6 h after the injury. Heart rate, mean arterial pressure, neutrophil count, and plasma adrenaline level were significantly lower in the hypothermic pigs. The arterial oxygen tension was significantly elevated in the hypothermic group as well.
Cooling catheter for spinal cord preservation in thoracic aortic surgery
Cooling catheter for spinal cord preservation in thoracic aortic surgery
R.M.A.MOOMIAIE, J.RANSDEN, J.STEIN, J.STRUGAR, Q.B.ZHU, J.H.KIM, J.A.ELEFTERIADES
J CARDIOVASC SURG, 2007
A self-contained catheter designed to cool the spinal cord topically after being threaded into the spinal column was tested in five adult sheep. core body temperature and spinal cord temperature in both active cooling and passive re-warming cycles were monitored. In four sheep, (five attempted implants, with one failure), the catheter worked without problem. There was no evidence of damage to the spinal cord from hypothermia. Effective topical cooling of the spinal cord can be achieved via a specially designed, self-contained cooling catheter placed into the intra-thecal space.
HYPOTHERMIA INCREASES THE THRESHOLD FOR ISCHEMIC PRECONDITIONING
HYPOTHERMIA INCREASES THE THRESHOLD FOR ISCHEMIC PRECONDITIONING
Kentaro Dote, Roger A. Wolff, Donna M. Van Winkle
The Journal of Thoracic and Cardiovascular Surgery, 1998Rabbit hearts underwent 45 minutes of regional ischemia, followed by 2 hours of reperfusion. Either normothermic or hypothermic ischemic preconditioning was elicited by either one or four periods of 5 minutes of regional ischemia. Normothermic ischemic preconditioning with one cycle had a 58% reduction and four cycles had a 95% reduction. Hypothermic ischemic preconditioning with four cycles of 5-minute coronary occlusions resulted in a 94% reduction of infarct size but hypothermic ischemic preconditioning with one cycle resulted in no reduction of infarct size. Myocardial glycogen and lactate levels were maintained near control levels during hypothermic ischemia. Hypothermia during the preconditioning period increases the threshold for eliciting the infarct limitation of ischemic preconditioning.
Measuring quality of life outcomes in spine clinical trials
Measuring quality of life outcomes in spine clinical trials
Michael G Fehlings
J Neurosurg Spine, 2009
According to Dr. Michael Fehlings, quality of life includes the impact of condition and its treatment on the person’s emotional, physical, and social functioning lifestyle. Clinicians are strongly swayed by their clinical experience since there is no certain standard to measure quality of life, although categorization is normally done in the form of a rating scale. This can relate to the severity observable on radiological imaging, neurological examination findings, or impairment of daily activities. Future work should be done to examine the advantages and disadvantages of existing scales and to be specifically suited to a spinal surgical trial.
Hypothermic Cardiopulmonary Bypass for Spinal Cord Protection: Rationale and Clinical Results
Hypothermic Cardiopulmonary Bypass for Spinal Cord Protection: Rationale and Clinical Results
Nicholas T. Kouchoukos, and Chris K. Rokkas
The Society of Thoracic Surgeons, 1999
During a 12-year period, 114 patients with descending thoracic or thoracoabdominal aortic disease underwent replacement of the involved aortic segments using hypothermic cardiopulmonary bypass and intervals of circulatory arrest. The hospital mortality was 8% (9 patients). Paraplegia occurred in 2 and paraparesis in 1 of the 108 patients whose lower limb function was assessed postoperatively (2.8%). None of 40 patients with aortic dissection and none of the last 81 patients in the series developed paralysis. hypothermic cardiopulmonary bypass and circulatory arrest confirms that hypothermia provides substantial protection against paraplegia.