Category: Hypothermia Research Papers

Posted on

Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis

Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis
H. Bartvander Worp, Emily S. Sena, Geoffrey A. Donnan, David W. Howells and Malcolm R. Macleod
Brain, 2007

Animal studies of induced hypothermia in focal cerebral ischaemia have tested cooling throughout a wide range of target temperatures, durations and intervals between stroke onset and the initiation of hypothermia.Data from 3353 animals show hypothermia reduced infarct size by 44%. In animal models of focal cerebral ischaemia, hypothermia improves outcome by about one-third.

Posted on

Influence of early posttraumatic hypothermia therapy on local cerebral blood flow and glucose metabolism after fluid-percussion brain injury

Influence of early posttraumatic hypothermia therapy on local cerebral blood flow and glucose metabolism after fluid-percussion brain injury
WEIZHAO ZHAO, OFELIA F. ALONSO., JUDITH Y. LOOR, RAUL BUSTO, AND MYRON D. GINSBERG
J Neurosurg, 1999

Rats were induced in either cranial hypothermia (30ºC) or normothermia (37ºC) for three hours after fluid-percussion head injury to assess local cerebral metabolic rate of glucose (LCMRglu) and local cerebral blood flow (LCBF). The LCMRglu/LCBF ratio was nearly doubled in the group that received cranial hypothermia relative to the rats that received normothermia.

Posted on

Posttraumatic Hypothermia followed by Slow Rewarming Protects the Cerebral Microcirculation

Posttraumatic Hypothermia followed by Slow Rewarming Protects the Cerebral Microcirculation
EIICHI SUEHIRO, YUJI UEDA, ENOCH P. WEI, HERMES A. KONTOS, and JOHN T. POVLISHOCK
J of Neurotrauma, 2003

Rats were prepared for assessment of microcirculation prior to and after traumatic brain injury. It was found that posttraumatic hypothermia followed by slow rewarming maintained normal responses in terms of ACh-dependent dilation and CO2 reactivity. In contrast, rats subjected to traumatic brain injury followed by normothermia or hypothermia and rapid rewarming showed impaired vasoreactivity in terms of their ACh-dependent and CO2 responses. This study demonstrates that the neuroprotective effects extend to the cerebral microcirculation.

Posted on

Hypothermic Preconditioning Increases Survival of Purkinje Neurons in Rat Cerebellar Slices after an In Vitro Simulated Ischemia

Hypothermic Preconditioning Increases Survival of Purkinje Neurons in Rat Cerebellar Slices after an In Vitro Simulated Ischemia
Hui-Bih Yuan, Yueming Huang, Shuqiu Zheng, Zhiyi Zuo
Anesthesiology, 2004

Rat cerebellar cells were deprived of oxygen-glucose for 20 minutes to simulate an ischemic event in vitro. Mild hypothermia of 33ºC was applied to the cells at various times before oxygen-glucose deprivation for 20 minutes. It was found that providing hypothermia before ischemia was able to provide a phase of neuroprotection.