Hypothermic Preconditioning Increases Survival of Purkinje Neurons in Rat Cerebellar Slices after an In Vitro Simulated Ischemia
Hui-Bih Yuan, Yueming Huang, Shuqiu Zheng, Zhiyi Zuo
Rat cerebellar cells were deprived of oxygen-glucose for 20 minutes to simulate an ischemic event in vitro. Mild hypothermia of 33ºC was applied to the cells at various times before oxygen-glucose deprivation for 20 minutes. It was found that providing hypothermia before ischemia was able to provide a phase of neuroprotection.