The effect of epidural cooling on lipid peroxidation after experimental spinal cord injury
S Tuzgen, MY Kaynar, A Guner, K Gumustas, A Belce, V Etus and E Ozyurt
Spinal Cord, 1998
A clip compression method was used to produce acute spinal cord injury in rats. There were five rats in group I (sham-operated), seven rats in group II (trauma), and eight rats in group III (epidural cooling). The extent of lipid peroxidation in the spinal cord was assessed by measuring the tissue content of malonil dialdehyde (MDA). The tissue MDA contents were 1.58 micromol MDA/gram wet weight (gww) in group I, 2.58 micromol MDA/gww in group II, and 1.77 micromol/gww in group III. The results indicated that epidural cooling of traumatized spinal cord is effective in preventing secondary damage due to the peroxidation of lipid membranes.