Hemmen TM; Raman R; Guluma KZ; Meyer BC; Gomes JA; Cruz-Flores S; Wijman CA; Rapp KS; Grotta JC; Lyden
Stroke, 2010
The feasibility and safety of hypothermia and thrombolysis after acute ischemic stroke was studied in humans. Twenty-eight patients randomized to receive hypothermia and 30 to normothermia. At 3 months, 18% of patients treated with hypothermia had a modified Rankin Scale score of 0 or 1 versus 24% in the normothermia groups. This study demonstrates the feasibility and preliminary safety of combining endovascular hypothermia after stroke with thrombolysis.