Rapid induction of brain hypothermia by endovascular intra-arterial perfusion
Motomasa Furuse, Mark C. Preul, Yoshihiko Kinoshita, Kentaro Nishihara, Naofumi Isono and Toshihiko Kuroiwa
Neurological Research, 2007
Ringer’s solution cooled to approximately 6.5ºC l/kg/min for 30 minutes was infused into the right common carotid artery in six adult canines. Right brain temperature decreased from 37.7 +/- 1.1ºC to 33.6 +/- 2.0ºC 30 minutes after initiation of perfusion. The cooling rate of the right cerebral hemisphere was 4.2 +/- 1.1 degrees C/ 30 minutes. Brain hypothermia was rapidly and safely induced using an intra-arterial crystalloid infusion.