Cerebral Metabolism and Blood Flow after Circulatory Arrest During Deep Hypothermia

Rapid induction of brain hypothermia by endovascular intra-arterial perfusion
Motomasa Furuse, Mark C. Preul, Yoshihiko Kinoshita, Kentaro Nishihara, Naofumi Isono and Toshihiko Kuroiwa
Neurological Research, 2007

The effects of hypothermia and circulatory arrest on cerebral blood flow and cerebral oxygen in dogs 10 dogs was studied. Dogs underwent deep hypothermia and circulatory arrest for 45 minutes. Cerebral oxygen consumption after circulatory arrest and rewarming increased by 15%. The cerebral blood flow decreased by 18% and cerebral vascular resistance increased by 8%. Surface induced hypothermia with anesthesia was tolerated by the dogs with no evidence of impairment of cerebral metabolism.