Effect of Moderate Hypothermia on Lipid Peroxidation in Canine Brain Tissue After Cardiac Arrest and Resuscitation
Lei Baiping, Tan Xiujuan, Cai Hongwei, Xu Qiming, Guo Quling
Twenty-one dogs were divided into four groups: group A, nonischemic controls (shams); group B, 15-minute cardiac arrest without reperfusion; group C, 15-minute cardiac arrest and standard resuscitation; and group D, 15-minute cardiac arrest and hypothermic resuscitation. All dogs in groups C and D were successfully resuscitated. In cardiac arrest group D, after 2 hours of hypothermic reperfusion, there were lower values for tissue malondialdehyde and higher values for glutathione , superoxide dismutase , and glutathione peroxidase compared with normothermic resuscitation in group C. Moderate hypothermia initiated after resuscitation can significantly help the accumulation of lipid peroxidation products and the consumption of free radical scavengers in the brain tissue.