Prolonged hypothermia protects neonatal rat brain against hypoxic-ischemia by reducing both apoptosis and necrosis
A.Ohmura, W Nakajima, A. Ishida, N. Yasuoka, M. Kawamura, S. Miura, G. Takada
Brain & Development, 2005
The effects of prolonged hypothermia on immature rat brain after hypoxic-ischemic injury and its protective mechanisms were examined by splitting the pups into a hypothermia group and a normothermia group. Prolonged hypothermia significantly reduced macroscopic brain injury, apoptotic cells, and necrotic cells. Results show that prolonged hypothermia protects neonatal brain after hypoxic-ischemic injury.