Mild Hypothermia and Mg++ Protect Against Irreversible Damage During CNS Ischemia
FRANCIS X. VACANTI, ADELBERT AMES III
Stroke, 1984
Spinal cord ischemia was produced in rabbits by temporary occlusion of the abdominal aorta. Recovery, or failure to recover was assessed by examining the rabbits for permanent loss of sensory and motor function in the hind limbs. A temperature reduction of 3ºC during the period of circulatory impairment caused a doubling of the duration of ischemia that could be reversibly sustained. A combination of 5 mmoles/kg of MgCl2 and the 3ºC reduction tripled the duration of ischemia that could be sustained before irreversible damage occurred.